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OCT4 supports extended LIF-independent self-renewal and maintenance of transcriptional and epigenetic networks in embryonic stem cells

Embryonic stem (ES) cell pluripotency is governed by OCT4-centric transcriptional networks. Conventional ES cells can be derived and maintained in vitro with media containing the cytokine leukemia inhibitory factor (LIF), which propagates the pluripotent state by activating STAT3 signaling, and simu...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: He, Runsheng, Xhabija, Besa, Al-Qanber, Batool, Kidder, Benjamin L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703885/
https://ncbi.nlm.nih.gov/pubmed/29180818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16611-y
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