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Nav channel binder containing a specific conjugation-site based on a low toxicity β-scorpion toxin

Voltage-gated sodium (Nav) channels play a key role in generating action potentials which leads to physiological signaling in excitable cells. The availability of probes for functional studies of mammalian Nav is limited. Here, by introducing two amino acid substitutions into the beta scorpion toxin...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kubota, Tomoya, Dang, Bobo, Carvalho-de-Souza, Joao L., Correa, Ana M., Bezanilla, Francisco
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703725/
https://ncbi.nlm.nih.gov/pubmed/29180755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16426-x
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