Deleting the mouse Hsd17b1 gene results in a hypomorphic Naglu allele and a phenotype mimicking a lysosomal storage disease

HSD17B1 is a steroid metabolising enzyme. We have previously generated knockout mice that had the entire coding region of Hsd17b1 replaced with lacZ-neo cassette (Hsd17b1-LacZ/Neo mice). This resulted in a 90% reduction of HSD17B1 activity, associated with severe subfertility in the knockout females...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Jokela, Heli, Hakkarainen, Janne, Kätkänaho, Laura, Pakarinen, Pirjo, Ruohonen, Suvi T., Tena-Sempere, Manuel, Zhang, Fu-Ping, Poutanen, Matti
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703720/
https://ncbi.nlm.nih.gov/pubmed/29180785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16618-5
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