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Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals

Dysfunction of the oxidative phosphorylation (OXPHOS) system is a major cause of human disease and the cellular consequences are highly complex. Here, we present comparative analyses of mitochondrial proteomes, cellular transcriptomes and targeted metabolomics of five knockout mouse strains deficien...

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Publicat a:eLife
Autors principals: Kühl, Inge, Miranda, Maria, Atanassov, Ilian, Kuznetsova, Irina, Hinze, Yvonne, Mourier, Arnaud, Filipovska, Aleksandra, Larsson, Nils-Göran
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703644/
https://ncbi.nlm.nih.gov/pubmed/29132502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.30952
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