Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8

Human regulatory T cells (Tregs) suppress other T cells by converting the latent, inactive form of TGF-β1 into active TGF-β1. In Tregs, TGF-β1 activation requires GARP, a transmembrane protein that binds and presents latent TGF-β1 on the surface of Tregs stimulated through their T cell receptor. How...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Stockis, Julie, Liénart, Stéphanie, Colau, Didier, Collignon, Amandine, Nishimura, Stephen L., Sheppard, Dean, Coulie, Pierre G., Lucas, Sophie
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703296/
https://ncbi.nlm.nih.gov/pubmed/29109269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710680114
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