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Targeting immunosuppression by Tregs with monoclonal antibodies against GARP

Reducing Treg function in cancer patients should augment antitumor immune responses. We recently uncovered a mechanism of immunosuppression by human Tregs that implies transmembrane protein GARP and production of active TGF-ß1. We obtained monoclonal antibodies that block this process and could thus...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Liénart, Stéphanie, Stockis, Julie, Dedobbeleer, Olivier, Lucas, Sophie
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839316/
https://ncbi.nlm.nih.gov/pubmed/27141368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1074379
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