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Targeting immunosuppression by Tregs with monoclonal antibodies against GARP
Reducing Treg function in cancer patients should augment antitumor immune responses. We recently uncovered a mechanism of immunosuppression by human Tregs that implies transmembrane protein GARP and production of active TGF-ß1. We obtained monoclonal antibodies that block this process and could thus...
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| 發表在: | Oncoimmunology |
|---|---|
| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Taylor & Francis
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4839316/ https://ncbi.nlm.nih.gov/pubmed/27141368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1074379 |
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