Treg-mediated prolonged survival of skin allografts without immunosuppression

Injection of Interleukin-2 (IL-2) complexed with a particular anti–IL-2 monoclonal antibody (mab) JES6-1 has been shown to selectively expand CD4(+)Foxp3(+) T regulatory T cells (Tregs) in vivo. Although the potency of this approach with regard to transplantation has already been proven in an islet...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Pilat, Nina, Wiletel, Mario, Weijler, Anna M., Steiner, Romy, Mahr, Benedikt, Warren, Joanna, Corpuz, Theresa M., Wekerle, Thomas, Webster, Kylie E., Sprent, Jonathan
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2019
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6613183/
https://ncbi.nlm.nih.gov/pubmed/31196957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903165116
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