Epoxide metabolites of arachidonate and docosahexaenoate function conversely in acute kidney injury involved in GSK3β signaling

Acute kidney injury (AKI) causes severe morbidity and mortality for which new therapeutic strategies are needed. Docosahexaenoic acid (DHA), arachidonic acid (ARA), and their metabolites have various effects in kidney injury, but their molecular mechanisms are largely unknown. Here, we report that 1...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Deng, Bing-Qing, Luo, Ying, Kang, Xin, Li, Chang-Bin, Morisseau, Christophe, Yang, Jun, Lee, Kin Sing Stephen, Huang, Jian, Hu, Da-Yong, Wu, Ming-Yu, Peng, Ai, Hammock, Bruce D., Liu, Jun-Yan
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703276/
https://ncbi.nlm.nih.gov/pubmed/29109264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705615114
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