Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin’s glucose-lowering effects

Treatment of type 2 diabetes mellitus continues to pose an important clinical challenge, with most existing therapies lacking demonstrable ability to improve cardiovascular outcomes. The atheroprotective peptide apelin (APLN) enhances glucose utilization and improves insulin sensitivity. However, th...

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Publicat a:Sci Transl Med
Autors principals: Hwangbo, Cheol, Wu, Jingxia, Papangeli, Irinna, Adachi, Takaomi, Sharma, Bikram, Park, Saejeong, Zhao, Lina, Ju, Hyekyung, Go, Gwang-woong, Cui, Guoliang, Inayathullah, Mohammed, Job, Judith K., Rajadas, Jayakumar, Kwei, Stephanie L., Li, Ming O., Morrison, Alan R., Quertermous, Thomas, Mani, Arya, Red-Horse, Kristy, Chun, Hyung J.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703224/
https://ncbi.nlm.nih.gov/pubmed/28904225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aad4000
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