Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin’s glucose-lowering effects

Treatment of type 2 diabetes mellitus continues to pose an important clinical challenge, with most existing therapies lacking demonstrable ability to improve cardiovascular outcomes. The atheroprotective peptide apelin (APLN) enhances glucose utilization and improves insulin sensitivity. However, th...

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Publicado no:Sci Transl Med
Main Authors: Hwangbo, Cheol, Wu, Jingxia, Papangeli, Irinna, Adachi, Takaomi, Sharma, Bikram, Park, Saejeong, Zhao, Lina, Ju, Hyekyung, Go, Gwang-woong, Cui, Guoliang, Inayathullah, Mohammed, Job, Judith K., Rajadas, Jayakumar, Kwei, Stephanie L., Li, Ming O., Morrison, Alan R., Quertermous, Thomas, Mani, Arya, Red-Horse, Kristy, Chun, Hyung J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703224/
https://ncbi.nlm.nih.gov/pubmed/28904225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aad4000
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