Leptin-induced transphosphorylation of vascular endothelial growth factor receptor increases Notch and stimulates endothelial cell angiogenic transformation

Leptin increases vascular endothelial growth factor (VEGF), VEGF receptor-2 (VEGFR-2), and Notch expression in cancer cells, and transphosphorylates VEGFR-2 in endothelial cells. However, the mechanisms involved in leptin’s actions in endothelial cells are not completely known. Here we investigated...

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Publicado en:Int J Biochem Cell Biol
Main Authors: Lanier, Viola, Gillespie, Corey, Leffers, Merle, Daley-Brown, Danielle, Milner, Joy, Lipsey, Crystal, Webb, Nia, Anderson, Leonard M., Newman, Gale, Waltenberger, Johannes, Gonzalez-Perez, Ruben Rene
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703053/
https://ncbi.nlm.nih.gov/pubmed/27590851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2016.08.023
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