Interphotoreceptor retinoid–binding protein removes all-trans-retinol and retinal from rod outer segments, preventing lipofuscin precursor formation

Interphotoreceptor retinoid–binding protein (IRBP) is a specialized lipophilic carrier that binds the all-trans and 11-cis isomers of retinal and retinol, and this facilitates their transport between photoreceptors and cells in the retina. One of these retinoids, all-trans-retinal, is released in th...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Chen, Chunhe, Adler, Leopold, Goletz, Patrice, Gonzalez-Fernandez, Federico, Thompson, Debra A., Koutalos, Yiannis
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5702674/
https://ncbi.nlm.nih.gov/pubmed/28972139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.795187
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