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T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes
Defects in T cell receptor (TCR) repertoire are proposed to predispose to autoimmunity. Here we show, by analyzing >2 × 10(8) TCRB sequences of circulating naive, central memory, regulatory and stem cell-like memory CD4(+) T cell subsets from patients with type 1 diabetes and healthy donors, that...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5702608/ https://ncbi.nlm.nih.gov/pubmed/29176645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01925-2 |
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