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Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine

Intestinal Paneth cells limit bacterial invasion by secreting antimicrobial proteins including lysozyme. However, invasive pathogens can disrupt the Golgi apparatus, interfering with secretion and compromising intestinal antimicrobial defense. Here we show that during bacterial infection, lysozyme i...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Bel, Shai, Pendse, Mihir, Wang, Yuhao, Li, Yun, Ruhn, Kelly A., Hassell, Brian, Leal, Tess, Winter, Sebastian E., Xavier, Ramnik J., Hooper, Lora V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5702267/
https://ncbi.nlm.nih.gov/pubmed/28751470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aal4677
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