Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine

Intestinal Paneth cells limit bacterial invasion by secreting antimicrobial proteins including lysozyme. However, invasive pathogens can disrupt the Golgi apparatus, interfering with secretion and compromising intestinal antimicrobial defense. Here we show that during bacterial infection, lysozyme i...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Science
Prif Awduron: Bel, Shai, Pendse, Mihir, Wang, Yuhao, Li, Yun, Ruhn, Kelly A., Hassell, Brian, Leal, Tess, Winter, Sebastian E., Xavier, Ramnik J., Hooper, Lora V.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5702267/
https://ncbi.nlm.nih.gov/pubmed/28751470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aal4677
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