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Mosaic autosomal aneuploidies are detectable from single-cell RNAseq data

BACKGROUND: Aneuploidies are copy number variants that affect entire chromosomes. They are seen commonly in cancer, embryonic stem cells, human embryos, and in various trisomic diseases. Aneuploidies frequently affect only a subset of cells in a sample; this is known as “mosaic” aneuploidy. A cell t...

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Vydáno v:BMC Genomics
Hlavní autoři: Griffiths, Jonathan A., Scialdone, Antonio, Marioni, John C.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5702132/
https://ncbi.nlm.nih.gov/pubmed/29178830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-017-4253-x
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