CRISPR/Cas9-mediated targeted chromosome elimination

BACKGROUND: The CRISPR/Cas9 system has become an efficient gene editing method for generating cells carrying precise gene mutations, including the rearrangement and deletion of chromosomal segments. However, whether an entire chromosome could be eliminated by this technology is still unknown. RESULT...

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I publikationen:Genome Biol
Huvudupphovsmän: Zuo, Erwei, Huo, Xiaona, Yao, Xuan, Hu, Xinde, Sun, Yidi, Yin, Jianhang, He, Bingbing, Wang, Xing, Shi, Linyu, Ping, Jie, Wei, Yu, Ying, Wenqin, Wei, Wei, Liu, Wenjia, Tang, Cheng, Li, Yixue, Hu, Jiazhi, Yang, Hui
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2017
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701507/
https://ncbi.nlm.nih.gov/pubmed/29178945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1354-4
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