CRISPR/Cas9-mediated targeted chromosome elimination

BACKGROUND: The CRISPR/Cas9 system has become an efficient gene editing method for generating cells carrying precise gene mutations, including the rearrangement and deletion of chromosomal segments. However, whether an entire chromosome could be eliminated by this technology is still unknown. RESULT...

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Veröffentlicht in:Genome Biol
Hauptverfasser: Zuo, Erwei, Huo, Xiaona, Yao, Xuan, Hu, Xinde, Sun, Yidi, Yin, Jianhang, He, Bingbing, Wang, Xing, Shi, Linyu, Ping, Jie, Wei, Yu, Ying, Wenqin, Wei, Wei, Liu, Wenjia, Tang, Cheng, Li, Yixue, Hu, Jiazhi, Yang, Hui
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701507/
https://ncbi.nlm.nih.gov/pubmed/29178945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1354-4
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