Homology-mediated end joining-based targeted integration using CRISPR/Cas9

Targeted integration of transgenes can be achieved by strategies based on homologous recombination (HR), microhomology-mediated end joining (MMEJ) or non-homologous end joining (NHEJ). The more generally used HR is inefficient for achieving gene integration in animal embryos and tissues, because it...

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Veröffentlicht in:Cell Res
Hauptverfasser: Yao, Xuan, Wang, Xing, Hu, Xinde, Liu, Zhen, Liu, Junlai, Zhou, Haibo, Shen, Xiaowen, Wei, Yu, Huang, Zijian, Ying, Wenqin, Wang, Yan, Nie, Yan-Hong, Zhang, Chen-Chen, Li, Sanlan, Cheng, Leping, Wang, Qifang, Wu, Yan, Huang, Pengyu, Sun, Qiang, Shi, Linyu, Yang, Hui
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518881/
https://ncbi.nlm.nih.gov/pubmed/28524166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.76
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