Regulatory T cells control toxicity in a humanized model of IL-2 therapy

While patient selection and clinical management have reduced high-dose IL-2 (HDIL2) immunotherapy toxicities, the immune mechanisms that underlie HDIL2-induced morbidity remain unclear. Here we show that dose-dependent morbidity and mortality of IL-2 immunotherapy can be modeled in human immune syst...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Li, Yan, Strick-Marchand, Helene, Lim, Ai Ing, Ren, Jiazi, Masse-Ranson, Guillemette, Dan Li, Jouvion, Gregory, Rogge, Lars, Lucas, Sophie, Bin Li, Di Santo, James P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701141/
https://ncbi.nlm.nih.gov/pubmed/29176694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01570-9
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