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Second messenger analogues highlight unexpected substrate sensitivity of CD38: total synthesis of the hybrid “L-cyclic inosine 5′-diphosphate ribose”
The multifunctional, transmembrane glycoprotein human CD38 catalyses the synthesis of three key Ca(2+)-mobilising messengers, including cyclic adenosine 5′-diphosphate ribose (cADPR), and CD38 knockout studies have revealed the relevance of the related signalling pathways to disease. To generate inh...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5700923/ https://ncbi.nlm.nih.gov/pubmed/29170518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16388-0 |
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