CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5′-Diphosphate Ribose Template

Few inhibitors exist for CD38, a multifunctional enzyme catalyzing the formation and metabolism of the Ca(2+)-mobilizing second messenger cyclic adenosine 5′-diphosphoribose (cADPR). Synthetic, non-hydrolyzable ligands can facilitate structure-based inhibitor design. Molecular docking was used to re...

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Detalhes bibliográficos
Main Authors: Moreau, Christelle, Liu, Qun, Graeff, Richard, Wagner, Gerd K., Thomas, Mark P., Swarbrick, Joanna M., Shuto, Satoshi, Lee, Hon Cheung, Hao, Quan, Potter, Barry V. L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3686795/
https://ncbi.nlm.nih.gov/pubmed/23840430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066247
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