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Targeted Cell-to-Cell Delivery of Protein Payloads via the Granzyme-Perforin Pathway
There is great potential for engineering cellular therapeutics by repurposing biological systems. Here, we report utilization of the granzyme-perforin pathway of cytotoxic lymphocytes as a cell-to-cell protein delivery module. We designed and constructed granzyme B-derived chaperone molecules fused...
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| Publié dans: | Mol Ther Methods Clin Dev |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society of Gene & Cell Therapy
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5700818/ https://ncbi.nlm.nih.gov/pubmed/29201936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2017.10.003 |
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