Absolute Quantification of Amyloid Propagons by Digital Microfluidics

[Image: see text] The self-replicating properties of proteins into amyloid fibrils is a common phenomenon and underlies a variety of neurodegenerative diseases. Because propagation-active fibrils are chemically indistinguishable from innocuous aggregates and monomeric precursors, their detection req...

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Veröffentlicht in:Anal Chem
Hauptverfasser: Pfammatter, Manuela, Andreasen, Maria, Meisl, Georg, Taylor, Christopher G., Adamcik, Jozef, Bolisetty, Sreenath, Sánchez-Ferrer, Antoni, Klenerman, David, Dobson, Christopher M., Mezzenga, Raffaele, Knowles, Tuomas P. J., Aguzzi, Adriano, Hornemann, Simone
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2017
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700450/
https://ncbi.nlm.nih.gov/pubmed/28972786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.7b03279
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