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The directed evolution of ligand specificity in a GPCR and the unequal contributions of efficacy and affinity
G protein-coupled receptors (GPCRs) must discriminate between hundreds of related signal molecules. In order to better understand how GPCR specificity can arise from a common promiscuous ancestor, we used laboratory evolution to invert the specificity of the Saccharomyces cerevisiae mating receptor...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5700115/ https://ncbi.nlm.nih.gov/pubmed/29167562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16332-2 |
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