Pharmacokinetics and Safety of High-Dose Intravenous Valproic Acid in Healthy Subjects: A Dose Escalation Trial To Support Clinical Translational Studies

BACKGROUND: Valproic acid (VPA) has demonstrated beneficial effects in preclinical models of cancer, neurologic diseases, and traumatic injuries. The purpose of this trial (Clinicaltrials.gov NCT0195156) was to characterize the single-dose plasma pharmacokinetics of 15 to 150 mg/kg of intravenous VP...

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Detalhes bibliográficos
Publicado no:Clin Pharmacokinet
Main Authors: Georgoff, Patrick E., Nikolian, Vahagn C., Bonham, Tess, Pai, Manjunath P., Tafatia, Celia, Halaweish, Ihab, To, Kathleen, Watcharotone, Kuanwong, Parameswaran, Aishwarya, Lao, Ruijuan, Sun, Duxin, Alam, Hasan B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699961/
https://ncbi.nlm.nih.gov/pubmed/28497259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-017-0553-1
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