Transcriptomic Changes Following Valproic Acid Treatment Promote Neurogenesis and Minimize Secondary Brain Injury

BACKGROUND: Early treatment with valproic acid (VPA) has demonstrated benefit in pre-clinical models of traumatic brain injury (TBI), including smaller brain lesion size, decreased edema, reduced neurologic disability, and faster recovery. Mechanisms underlying these favorable outcomes are not fully...

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Udgivet i:J Trauma Acute Care Surg
Main Authors: Nikolian, Vahagn C., Dennahy, Isabel S., Higgins, Gerald A., Williams, Aaron M., Weykamp, Michael, Georgoff, Patrick E., Eidy, Hassan, Ghandour, Mohamed H., Chang, Panpan, Alam, Hasan B.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5905703/
https://ncbi.nlm.nih.gov/pubmed/29251707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TA.0000000000001765
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