Insulin-dependent metabolic and inotropic responses in the heart are modulated by hydrogen peroxide from NADPH-oxidase isoforms NOX2 and NOX4

RATIONALE: Hydrogen peroxide (H(2)O(2)) is a stable reactive oxygen species (ROS) that has long been implicated in insulin signal transduction in adipocytes. However, H(2)O(2)’s role in mediating insulin’s effects on the heart are unknown. OBJECTIVE: We investigated the role of H(2)O(2) in activatin...

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Bibliografiska uppgifter
I publikationen:Free Radic Biol Med
Huvudupphovsmän: Steinhorn, Benjamin, Sartoretto, Juliano L., Sorrentino, Andrea, Romero, Natalia, Kalwa, Hermann, Abel, E. Dale, Michel, Thomas
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699944/
https://ncbi.nlm.nih.gov/pubmed/28917508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.09.006
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