Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure

Abnormal folate one-carbon metabolism (FOCM) is implicated in neural tube defects (NTDs), severe malformations of the nervous system. MTHFR mediates unidirectional transfer of methyl groups from the folate cycle to the methionine cycle and, therefore, represents a key nexus in partitioning one-carbo...

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Publicado en:Cell Rep
Autores principales: Leung, Kit-Yi, Pai, Yun Jin, Chen, Qiuying, Santos, Chloe, Calvani, Enrica, Sudiwala, Sonia, Savery, Dawn, Ralser, Markus, Gross, Steven S., Copp, Andrew J., Greene, Nicholas D.E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cell Press 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699646/
https://ncbi.nlm.nih.gov/pubmed/29141214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.10.072
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