Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure

Abnormal folate one-carbon metabolism (FOCM) is implicated in neural tube defects (NTDs), severe malformations of the nervous system. MTHFR mediates unidirectional transfer of methyl groups from the folate cycle to the methionine cycle and, therefore, represents a key nexus in partitioning one-carbo...

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Publicado no:Cell Rep
Main Authors: Leung, Kit-Yi, Pai, Yun Jin, Chen, Qiuying, Santos, Chloe, Calvani, Enrica, Sudiwala, Sonia, Savery, Dawn, Ralser, Markus, Gross, Steven S., Copp, Andrew J., Greene, Nicholas D.E.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699646/
https://ncbi.nlm.nih.gov/pubmed/29141214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.10.072
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