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Neural tube defects induced by folate deficiency in mutant curly tail (Grhl3) embryos are associated with alteration in folate one-carbon metabolism but are unlikely to result from diminished methylation

BACKGROUND: Folate one-carbon metabolism has been implicated as a determinant of susceptibility to neural tube defects (NTDs), owing to the preventive effect of maternal folic acid supplementation and the higher risk associated with markers of diminished folate status. METHODS: Folate one-carbon met...

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Detalhes bibliográficos
Main Authors: De Castro, Sandra CP, Leung, Kit-yi, Savery, Dawn, Burren, Katie, Rozen, Rima, Copp, Andrew J., Greene, Nicholas D.E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3634156/
https://ncbi.nlm.nih.gov/pubmed/20589880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bdra.20690
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