The catalytic mechanism of cyclic GMP‐AMP synthase (cGAS) and implications for innate immunity and inhibition

Cyclic GMP‐AMP synthase (cGAS) is activated by ds‐DNA binding to produce the secondary messenger 2′,3′‐cGAMP. cGAS is an important control point in the innate immune response; dysregulation of the cGAS pathway is linked to autoimmune diseases while targeted stimulation may be of benefit in immunonco...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Protein Sci
Hoofdauteurs: Hall, Justin, Ralph, Erik C., Shanker, Suman, Wang, Hong, Byrnes, Laura J., Horst, Reto, Wong, Jimson, Brault, Amy, Dumlao, Darren, Smith, James F., Dakin, Leslie A., Schmitt, Daniel C., Trujillo, John, Vincent, Fabien, Griffor, Matt, Aulabaugh, Ann E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2017
Onderwerpen:
Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699495/
https://ncbi.nlm.nih.gov/pubmed/28940468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3304
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items