Induced pluripotent HD monkey stem cells derived neural cells for drug discovery

Huntington’s disease (HD) is a neurodegenerative disease caused by an expansion of CAG trinucleotide repeat (polyglutamine; polyQ) in the huntingtin (HTT) gene which leads to the formation of mutant HTT (mHTT) protein aggregates. In the nervous system, an accumulation of mHTT protein results in glut...

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Bibliografiske detaljer
Udgivet i:SLAS Discov
Main Authors: Kunkanjanawan, Tanut, Carter, Richard, Ahn, Kwan-Sung, Yang, Jinjing, Parnpai, Rangsun, Chan, Anthony W.S.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699456/
https://ncbi.nlm.nih.gov/pubmed/28027448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555216685044
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