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Induced pluripotent HD monkey stem cells derived neural cells for drug discovery
Huntington’s disease (HD) is a neurodegenerative disease caused by an expansion of CAG trinucleotide repeat (polyglutamine; polyQ) in the huntingtin (HTT) gene which leads to the formation of mutant HTT (mHTT) protein aggregates. In the nervous system, an accumulation of mHTT protein results in glut...
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| Publié dans: | SLAS Discov |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5699456/ https://ncbi.nlm.nih.gov/pubmed/28027448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555216685044 |
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