Inhibition of curli assembly and Escherichia coli biofilm formation by the human systemic amyloid precursor transthyretin

During biofilm formation, Escherichia coli and other Enterobacteriaceae produce an extracellular matrix consisting of curli amyloid fibers and cellulose. The precursor of curli fibers is the amyloidogenic protein CsgA. The human systemic amyloid precursor protein transthyretin (TTR) is known to inhi...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Jain, Neha, Ådén, Jörgen, Nagamatsu, Kanna, Evans, Margery L., Li, Xinyi, McMichael, Brennan, Ivanova, Magdalena I., Almqvist, Fredrik, Buxbaum, Joel N., Chapman, Matthew R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699053/
https://ncbi.nlm.nih.gov/pubmed/29087319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708805114
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