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The role of genomic location and flanking 3′UTR in the generation of functional levels of variant surface glycoprotein in Trypanosoma brucei

Trypanosoma brucei faces relentless immune attack in the mammalian bloodstream, where it is protected by an essential coat of Variant Surface Glycoprotein (VSG) comprising ∼10% total protein. The active VSG gene is in a Pol I‐transcribed telomeric expression site (ES). We investigated factors mediat...

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Bibliografski detalji
Izdano u:Mol Microbiol
Glavni autori: Ridewood, Sophie, Ooi, Cher‐Pheng, Hall, Belinda, Trenaman, Anna, Wand, Nadina Vasileva, Sioutas, Georgios, Scherwitzl, Iris, Rudenko, Gloria
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698767/
https://ncbi.nlm.nih.gov/pubmed/28906055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.13838
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