The role of genomic location and flanking 3′UTR in the generation of functional levels of variant surface glycoprotein in Trypanosoma brucei

Trypanosoma brucei faces relentless immune attack in the mammalian bloodstream, where it is protected by an essential coat of Variant Surface Glycoprotein (VSG) comprising ∼10% total protein. The active VSG gene is in a Pol I‐transcribed telomeric expression site (ES). We investigated factors mediat...

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Detalhes bibliográficos
Publicado no:Mol Microbiol
Main Authors: Ridewood, Sophie, Ooi, Cher‐Pheng, Hall, Belinda, Trenaman, Anna, Wand, Nadina Vasileva, Sioutas, Georgios, Scherwitzl, Iris, Rudenko, Gloria
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698767/
https://ncbi.nlm.nih.gov/pubmed/28906055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.13838
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