Blocking Variant Surface Glycoprotein Synthesis in Trypanosoma brucei Triggers a General Arrest in Translation Initiation

BACKGROUND: The African trypanosome Trypanosoma brucei is covered with a dense layer of Variant Surface Glycoprotein (VSG), which protects it from lysis by host complement via the alternative pathway in the mammalian bloodstream. Blocking VSG synthesis by the induction of VSG RNAi triggers an unusua...

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Detalhes bibliográficos
Main Authors: Smith, Terry K., Vasileva, Nadina, Gluenz, Eva, Terry, Stephen, Portman, Neil, Kramer, Susanne, Carrington, Mark, Michaeli, Shulamit, Gull, Keith, Rudenko, Gloria
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2762041/
https://ncbi.nlm.nih.gov/pubmed/19855834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007532
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