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Blocking Variant Surface Glycoprotein Synthesis in Trypanosoma brucei Triggers a General Arrest in Translation Initiation

BACKGROUND: The African trypanosome Trypanosoma brucei is covered with a dense layer of Variant Surface Glycoprotein (VSG), which protects it from lysis by host complement via the alternative pathway in the mammalian bloodstream. Blocking VSG synthesis by the induction of VSG RNAi triggers an unusua...

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Bibliografiske detaljer
Main Authors: Smith, Terry K., Vasileva, Nadina, Gluenz, Eva, Terry, Stephen, Portman, Neil, Kramer, Susanne, Carrington, Mark, Michaeli, Shulamit, Gull, Keith, Rudenko, Gloria
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2762041/
https://ncbi.nlm.nih.gov/pubmed/19855834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007532
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