The role of genomic location and flanking 3′UTR in the generation of functional levels of variant surface glycoprotein in Trypanosoma brucei

Trypanosoma brucei faces relentless immune attack in the mammalian bloodstream, where it is protected by an essential coat of Variant Surface Glycoprotein (VSG) comprising ∼10% total protein. The active VSG gene is in a Pol I‐transcribed telomeric expression site (ES). We investigated factors mediat...

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Detalles Bibliográficos
Publicado en:Mol Microbiol
Main Authors: Ridewood, Sophie, Ooi, Cher‐Pheng, Hall, Belinda, Trenaman, Anna, Wand, Nadina Vasileva, Sioutas, Georgios, Scherwitzl, Iris, Rudenko, Gloria
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2017
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698767/
https://ncbi.nlm.nih.gov/pubmed/28906055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.13838
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