Mycobacterium tuberculosis Latent Antigen Rv2029c from the Multistage DNA Vaccine A39 Drives TH1 Responses via TLR-mediated Macrophage Activation

Targeting of Mycobacterium tuberculosis (MTB) latent antigens comprises a crucial strategy for the development of alternative tuberculosis (TB) vaccine(s) that protects against TB reactivation. Here, we generated a multistage DNA vaccine, A39, containing the early antigens Ag85A and Rv3425 as well a...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Su, Haibo, Zhu, Shengling, Zhu, Lin, Kong, Cong, Huang, Qi, Zhang, Zhi, Wang, Honghai, Xu, Ying
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698697/
https://ncbi.nlm.nih.gov/pubmed/29204139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2017.02266
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