Population pharmacokinetics and electrocardiographic effects of dihydroartemisinin–piperaquine in healthy volunteers

AIMS: The aims of the present study were to evaluate the pharmacokinetic properties of dihydroartemisinin (DHA) and piperaquine, potential drug–drug interactions with concomitant primaquine treatment, and piperaquine effects on the electrocardiogram in healthy volunteers. METHODS: The population pha...

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Dades bibliogràfiques
Publicat a:Br J Clin Pharmacol
Autors principals: Chotsiri, Palang, Wattanakul, Thanaporn, Hoglund, Richard M., Hanboonkunupakarn, Borimas, Pukrittayakamee, Sasithon, Blessborn, Daniel, Jittamala, Podjanee, White, Nicholas J., Day, Nicholas P.J., Tarning, Joel
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Pharmacokinetic Dynamic Relationships
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698590/
https://ncbi.nlm.nih.gov/pubmed/28695570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13372
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