Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication

Betacoronaviruses, such as Middle East respiratory syndrome coronavirus (MERS-CoV), are important pathogens causing potentially lethal infections in humans and animals. Coronavirus RNA synthesis is thought to be associated with replication organelles (ROs) consisting of modified endoplasmic reticulu...

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Veröffentlicht in:mBio
Hauptverfasser: Oudshoorn, Diede, Rijs, Kevin, Limpens, Ronald W. A. L., Groen, Kevin, Koster, Abraham J., Snijder, Eric J., Kikkert, Marjolein, Bárcena, Montserrat
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698553/
https://ncbi.nlm.nih.gov/pubmed/29162711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01658-17
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