Does oxidative damage to DNA increase with age?

The levels of 8-oxo-2-deoxyguanosine (oxo8dG) in DNA isolated from tissues of rodents (male F344 rats, male B6D2F1 mice, male C57BL/6 mice, and female C57BL/6 mice) of various ages were measured using sodium iodide to prevent oxidative damage to DNA during DNA isolation. Oxo8dG was measured in nucle...

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Detalhes bibliográficos
Main Authors: Hamilton, Michelle L., Van Remmen, Holly, Drake, Jessica A., Yang, Hong, Guo, Zhong Mao, Kewitt, Kristen, Walter, Christi A., Richardson, Arlan
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC56984/
https://ncbi.nlm.nih.gov/pubmed/11517304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.171202698
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