Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling

Nitroxyl anion (NO(−)) is the one-electron reduction product of nitric oxide (NO(⋅)) and is enzymatically generated by NO synthase in vitro. The physiologic activity and mechanism of action of NO(−) in vivo remains unknown. The NO(−) generator Angeli's salt (AS, Na(2)N(2)O(3)) was administered...

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Main Authors: Paolocci, Nazareno, Saavedra, Walter F., Miranda, Katrina M., Martignani, Cristian, Isoda, Takayoshi, Hare, Joshua M., Espey, Michael G., Fukuto, Jon M., Feelisch, Martin, Wink, David A., Kass, David A.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2001
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC56983/
https://ncbi.nlm.nih.gov/pubmed/11517312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.181191198
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