Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in early- and late-stage cholestasis

AIM: To ascertain whether cholestasis affects the expression of two CYP3A isoforms (CYP3A1 and CYP3A2) and of pregnane X receptor (PXR) and constitutive androstane receptor (CAR). METHODS: Cholestasis was induced by bile duct ligation in 16 male Wistar rats; whereas 8 sham-operated rats were used as...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:World J Gastroenterol
Main Authors: Gabbia, Daniela, Pozza, Arianna Dalla, Albertoni, Laura, Lazzari, Roberta, Zigiotto, Giorgia, Carrara, Maria, Baldo, Vincenzo, Baldovin, Tatjana, Floreani, Annarosa, Martin, Sara De
Formato: Artigo
Idioma:Inglês
Publicado em: Baishideng Publishing Group Inc 2017
Assuntos:
Basic Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698245/
https://ncbi.nlm.nih.gov/pubmed/29204052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v23.i42.7519
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados