Transient BAFF blockade inhibits type 1 diabetes development in NOD mice by enriching immunoregulatory B-lymphocytes sensitive to deletion by anti-CD20 co-therapy(, )

In NOD mice and also likely humans, B-lymphocytes play an important role as APC expanding autoreactive T-cell responses ultimately causing type 1 diabetes (T1D). Currently, humans at high future T1D risk can only be identified at late prodromal stages of disease indicated by markers such as insulin...

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Veröffentlicht in:J Immunol
Hauptverfasser: Wang, Qiming, Racine, Jeremy J, Ratiu, Jeremy J, Wang, Shu, Ettinger, Rachel, Wasserfall, Clive, Atkinson, Mark A, Serreze, David V
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698153/
https://ncbi.nlm.nih.gov/pubmed/29055002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700822
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