IFN-λ4 attenuates antiviral responses by enhancing negative regulation of interferon signaling

Type-III interferons (IFNs) are important mediators of antiviral immunity. IFN-λ4 is a unique type-III IFN because it is produced only in individuals who carry a dG allele of a genetic variant rs368234815-dG/TT. Counterintuitively, those individuals who can produce IFN-λ4, an antiviral cytokine, are...

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Publicat a:J Immunol
Autors principals: Obajemu, Adeola A., Rao, Nina, Dilley, Kari A., Vargas, Joselin M, Sheikh, Faruk, Donnelly, Raymond P., Shabman, Reed S., Meissner, Eric G., Prokunina-Olsson, Ludmila, Onabajo, Olusegun O.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698113/
https://ncbi.nlm.nih.gov/pubmed/29070670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700807
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