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A CRISPR screen identifies a pathway required for paraquat-induced cell death
Paraquat, a herbicide linked to Parkinson’s disease, generates reactive oxygen species (ROS) to cause cell death. Because the source of paraquat-induced ROS production remains unknown, we conducted a CRISPR-based positive selection screen to identify metabolic genes essential for paraquat-induced ce...
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| Publicado no: | Nat Chem Biol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5698099/ https://ncbi.nlm.nih.gov/pubmed/29058724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2499 |
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