Blocking TGF-β and β-Catenin Epithelial Crosstalk Exacerbates CKD

The TGF-β and Wnt/β-catenin pathways have important roles in modulating CKD, but how these growth factors affect the epithelial response to CKD is not well studied. TGF-β has strong profibrotic effects, but this pleiotropic factor has many different cellular effects depending on the target cell type...

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Bibliografische gegevens
Gepubliceerd in:J Am Soc Nephrol
Hoofdauteurs: Nlandu-Khodo, Stellor, Neelisetty, Surekha, Phillips, Melanie, Manolopoulou, Marika, Bhave, Gautam, May, Lauren, Clark, Peter E., Yang, Haichun, Fogo, Agnes B., Harris, Raymond C., Taketo, M. Mark, Lee, Ethan, Gewin, Leslie S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Nephrology 2017
Onderwerpen:
Basic Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698068/
https://ncbi.nlm.nih.gov/pubmed/28701516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016121351
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