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Independent impacts of aging on mitochondrial DNA quantity and quality in humans
BACKGROUND: The accumulation of mitochondrial DNA (mtDNA) mutations, and the reduction of mtDNA copy number, both disrupt mitochondrial energetics, and may contribute to aging and age-associated phenotypes. However, there are few genetic and epidemiological studies on the spectra of blood mtDNA hete...
Sparad:
I publikationen: | BMC Genomics |
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Huvudupphovsmän: | , , , , |
Materialtyp: | Artigo |
Språk: | Inglês |
Publicerad: |
BioMed Central
2017
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Ämnen: | |
Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5697406/ https://ncbi.nlm.nih.gov/pubmed/29157198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-017-4287-0 |
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