Single-cell multiplexed cytokine profiling of CD19 CAR-T cells reveals a diverse landscape of polyfunctional antigen-specific response

BACKGROUND: It remains challenging to characterize the functional attributes of chimeric antigen receptor (CAR)-engineered T cell product targeting CD19 related to potency and immunotoxicity ex vivo, despite promising in vivo efficacy in patients with B cell malignancies. METHODS: We employed a sing...

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Publicat a:J Immunother Cancer
Autors principals: Xue, Qiong, Bettini, Emily, Paczkowski, Patrick, Ng, Colin, Kaiser, Alaina, McConnell, Timothy, Kodrasi, Olja, Quigley, Máire F., Heath, James, Fan, Rong, Mackay, Sean, Dudley, Mark E., Kassim, Sadik H., Zhou, Jing
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5697351/
https://ncbi.nlm.nih.gov/pubmed/29157295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-017-0293-7
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