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In Vitro and In Vivo Comparison of Gemcitabine and the Gemcitabine Analog 1-(2′-deoxy-2′-fluoroarabinofuranosyl) Cytosine (FAC) in Human Orthotopic and Genetically Modified Mouse Pancreatic Cancer Models

PURPOSE: Although gemcitabine is a mainstay of pancreatic cancer therapy, it is only moderately effective, and it would be desirable to measure drug uptake in patients. 1-(2′-deoxy-2′-fluoroarabinofuranosyl) cytosine (FAC), is an analog of gemcitabine, and when labeled with F-18, it may be a potenti...

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Detalhes bibliográficos
Publicado no:Mol Imaging Biol
Main Authors: Russell, James, Pillarsetty, Nagavarakishore, Kramer, Robin M, Romesser, Paul B, Desai, Pooja, Haimovitz-Friedman, Adriana, Lowery, Maeve A, Humm, John L
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696795/
https://ncbi.nlm.nih.gov/pubmed/28349292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11307-017-1078-6
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