LDL receptor blockade reduces mortality in a mouse model of ischaemic stroke without improving tissue-type plasminogen activator-induced brain haemorrhage: towards pre-clinical simulation of symptomatic ICH

BACKGROUND: Symptomatic intracerebral haemorrhage (sICH) following tissue-type plasminogen activator (rt-PA) administration is the most feared and lethal complication of thrombolytic therapy for ischaemic stroke, creating a significant obstacle for a broader uptake of this beneficial treatment. rt-P...

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Detalhes bibliográficos
Publicado no:Fluids Barriers CNS
Main Authors: Niego, Be’eri, Broughton, Brad R. S., Ho, Heidi, Sobey, Christopher G., Medcalf, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696777/
https://ncbi.nlm.nih.gov/pubmed/29157263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12987-017-0081-2
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